The SAD Study
Brigham and Women’s Hospital
Are you currently being treated for depression but still feel depressed?
We are recruiting participants for a study investigating aspirin as a potential treatment for depression.
SAD stands for Salicylate Augmentation in Depression. This is a randomized, placebo-controlled clinical trial investigating whether aspirin can help to improve symptoms in people who are currently taking antidepressants but are still feeling depressed. The study is being conducted by researchers at Brigham and Women’s Hospital in Boston.
In order to participate in the SAD Study, you must meet the following criteria
- Between 18 and 65 years old
- Currently diagnosed with major depressive disorder
- NOT have any history of bipolar disorder, mania, or psychotic thinking
- Be taking the same medication dose for at least 8 weeks at the time that you start the study
Have none of the following major medical conditions
- neurologic (like seizures or Parkinson disease)
- autoimmune condition (like rheumatoid arthritis or lupus)
- infections (like HIV or hepatitis)
Do not take
- blood-thinning medications like warfarin, heparin, or enoxaparin
- anti-inflammatory medications like steroids or DAILY ibuprofen or naproxen (occasional use is ok).
If you are eligible to participate, you will be asked to take the study medication once a day and come to Brigham and Women’s Hospital for 4 separate study visits over the course of 8 weeks. The study visits will last between 45 minutes and 2 hours and will involve the following activities:
- Psychiatric evaluations
- Completing questionnaires
- Blood draw
- Urine collection
Yes, study participants can receive up to $200 in compensation. We can also provide parking vouchers if needed.
You can call the study coordinator at 857.307.1290 or send an email to SADSTUDY@PARTNERS.ORG with any questions.
Please include your phone number in your message if you wish to be contacted with more information.